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LONDON — The Japanese firm Kyowa Kirin is acquiring gene therapy maker Orchard Therapeutics in a $400 million deal, the companies said Thursday.

Kyowa Kirin is paying $16 per share — a nearly 100% premium on Orchard’s Wednesday closing price — in cash, amounting to roughly $390 million. Orchard shareholders stand to earn another $90 million if Orchard’s gene therapy, Libmeldy, wins U.S. approval. The transaction is expected to close early next year.

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Orchard, which has operations in London and Boston, has been one of the more successful companies at getting a gene therapy covered in European countries. The medicines, which deliver functional genes to patients to overcome their genetic diseases, are one-time treatments that can have profound effects for patients but that typically carry seven-figure price tags, leading to so far slow rollouts.

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